于荣敏，男，博士，二级教授、硕士生/博士生导师。现任永利集团中药生物技术研究所所长、天然药物化学教研室主任。

        先后承担国家及省部级等课题20余项，其中国家科技重大专项/重大新药创制2项、国家自然科学基金面上项目3项、国家教育部重点项目1项、广东省科技重大专项1项；发表学术论文300余篇，其中SCI论文80余篇；主编著作3部，副主编6部，参编13部。获发明专利证书8本，申请发明专利20余项。先后获省部级以上奖励5项，永利集团师德标兵、永利集团优秀教师、永利集团卓越导师；先后主讲本科生课程《Natural Medicinal Chemistry》、《天然药物化学》、《药学英语》、《药学导论》、《中药生物技术》、《中药学导论》和研究生课程《生物合成概论》、《中药生物技术进展》、《中药生物技术前沿与进展》等；培养硕士和博士研究生100余名，博士后7名。

主要研究方向：天然药物活性成分的生物合成和生物转化；中药及天然药物生物活性大分子（多肽、蛋白/多糖）的挖掘与发现；创新药物研究和开发。

主要学术与社会兼职：中国药学会生化与生物技术药物专业委员会副主任委员、国家“重大新药创制”科技重大专项评审专家、国家发展和改革委员会药品价格评审专家、中国中西医结合学会中药学专业委员会委员、中国自然资源学会天然药物资源专业委员会委员、中国生物化学与分子生物学学会海洋生物化学与分子生物学分会第三届理事会理事、山东省药学科学院专家委员会首席专家、广东省中药与天然药物专业委员会副主任委员等。曾任402永利集团官网中药学系主任等。现兼任《Pharmacognosy Magazine》（SCI）编委，中文核心期刊《中国生化药物杂志》副主编，《Drug Discoveries & Therapeutics》、《中国中药杂志》、《中草药》、《中药材》、《药物生物技术》、《食品与药品》、《药学研究》等杂志编委。

代表性论著：

(1) Huang Wei-Juan, Tian Xiao-Peng, Bi Si-Xue, Zhang Si-Rui, He Ting-Sha, Song Li-Yan, Yun Jing-Ping, Zhou Zhong-Guo, Yu Rong-Min, Li Mei. The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis. Oncogene, 2020: accepted.

(2) Sixue Bi, Weijuan Huang, Chunhua Huang, Chunlei Li, Zhongyi Guo, Jianing Yang, Xianjing Hu, Jianhua Zhu, Liyan Song, Rongmin Yu: Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAM and T lymphocytes. International Journal of Biological Macromolecules, 2020, 150: 261–280. 

(3) Chunlei Li, Chengguang Zhu, Biao Ren, Xin Yin, Sanghee Shim, Yue Gao, Jianhua Zhu, Changheng Liu, Xuekui Xia, Rongmin Yu, Lixin Zhang: An Optimized Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Staphylococcus aureus. European Journal of Medicinal Chemistry. 2019, 183: 111686.

(4) Chunlei Li, Yao Wen, Ying He, Jianhua Zhu, Xin Yin, Jianing Yang, Lixin  Zhang, Liyan Song, Xuekui Xia and Rongmin Yu: Purification and  characterization of a novel β-1,3-glucanase from Arca inflata and its immune-enhancing effects. Food Chemistry. 2019, 190: 1–9.

(5) Bao Peng, Jianing Yang, Weijuan Huang, Dan Peng, Sixue Bi, Liyan Song, Yao Wen, Jianhua Zhu, Yiyu Chen and Rongmin Yu: Structural characterization and immunoregulatory activity of a novel heteropolysaccharide from bergamot (Citrus medica L. var. sarcodactylis) by alkali extraction. Industrial Crops and Products. 2019, 140: 111617.

(6) Bao Peng, Yuanyuan Luo, Xianjing Hu, Liyan Song, Jianing Yang, Jianhua Zhu, Yao Wen, Rongmin Yu: Isolation, structural characterization, and immunostimulatory activity of a new water-soluble polysaccharide and its sulfated derivative from Citrus medica L. var. sarcodactylis. International Journal of Biological Macromolecules. 2019, 123: 500–511. 

(7) Juan Du, Jingjing Li, Jianhua Zhu, Chunhua Huang, Sixue Bi, Liyan Song, Xianjing Hu and Rongmin Yu: Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica. Food & Function. 2018, 9, 3930–3943.

(8) Jian Chen, Xiaona Fan, Jianhua Zhu, Liyan Song, Zhiwei Li, Fei Lin, Rongmin Yu, Hanhong Xu, Jiachen Zi: Limonoids from seeds of Azadiracchta indica A. Juss and their cytotoxic activity. Acta Pharmaceutica Sinica B. 2018, 8: 639–644. 

(9) Sixue Bi, Yongshuai Jing, Qinqin Zhou, Xianjing Hu, Jianhua Zhu, Zhongyi Guo, Liyan Song, Rongmin Yu: Structural elucidation and immunostimulatory activities of a new polysaccharide from Cordyceps militaris. Food & Function. 2018, 9, 279–293.

(10) Wenya Wang, Hui Shi, Jianhua Zhu, Chunlei Li, Liyan Song, Rongmin Yu: Purification and structural characterization of a novel antioxidant and antibacterial protein from Arca inflate. International Journal of Biological Macromolecules. 2018, 116: 289–298.

(11) Chunlei Li, Jianhua Zhu, Yanqing Wang, Yuyan Chen, Liyan Song, Weiming Zheng, Jingjing Li, Rongmin Yu: Antibacterial activity of AI-hemocidin 2, a novel N-terminal peptide of hemoglobin purified from Arca inflata. Marine Drugs. 2017, 15(7), 205.

(12) Jianhua Zhu, Jian Xu, Yanqing Wang, Chunlei Li, Zhiyan Chen, Liyan Song, Jingjing Gao, Rongmin Yu: Purification and structural characterization of a novel anti-tumor protein from Arca inflate. International Journal of Biological Macromolecules. 2017, 105: 103–110.

(13) Yuyan Chen, Chunlei Li, Jianhua Zhu, Wangshi Xie, Xianjing Hu, Liyan Song, Jiachen Zi and Rongmin Yu: Purification and characterization of an antibacterial and anti-inflammatory polypeptide from Arca subcrenata. International Journal of Biological Macromolecules. 2017, 96: 177–184.

(14) Zhang Zhang, Ren Xiaomei, Lu Xiaoyun,Wang Deping, Hu Xianjing, Zheng Yi, Song Liyan, Pang Hongwen, Yu Rongmin, Ding Ke, GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo. Cancer letters, 2016, 375: 172–178.  

(15) Wensong Tu, Jianhua Zhu, Sixue Bi, Dehong Chen, Liyan Song, Lishan Wang, Jiachen Zi, Rongmin Yu: Isolation, characterization and biological activities of a novel polysaccharide from pulp tissues of Annona squamosa and its sulfated derivative. Carbohydrate Polymers. 2016, 152: 287–296.

(16) Yongshuai Jing, Jianhua Zhu, Ting Liu, Sixue Bi, Xianjing Hu, Zhiyan Chen, Liyan Song, Wenjie Lv, Rongmin Yu: Structural characterization and biological activities of a novel polysaccharide from cultured Cordyceps militaris and its sulfated derivative. Journal of Agricultural and Food Chemistry. 2015, 63: 3464–3471.

(17) Pengfei Zhou, Jiazeng Yang, Jianhua Zhu, Shuijie He, Wenjin Zhang, Rongmin Yu, Jiachen Zi, Liyan Song, Xuesong Huang: Effects of β-cyclodextrin and methyl jasmonate on the production of vindoline, catharanthine and ajmalicine in Catharanthus roseus cambial meristematic cell cultures. Applied Microbiology and Biotechnology. 2015, 99: 7035–7045.

(18) Shuangshuang Lv, Jingjing Gao, Ting Liu, Jianhua Zhu, Jian Xu, Liyan Song, Jincai Liang, Rongmin Yu: Purification and partial characterization of a new antitumor protein from Tegillarca granosa. Marine Drugs. 2015, 13:1466–1480.

(19) Yongshuai Jing, Lijiao Huang, Wenjie Lv, Hui Tong, Liyan Song, Xuqiao Hu, Rongmin Yu: Structure characterization of a novel polysaccharide from pulp tissues of Litchi chinensis and its immnunomodulatory activity. Journal of Agricultural and Food Chemistry. 2014, 62: 902–911.

(20) Yongshuai Jing, Xinlu Cui, Zhiyan Chen, Lijiao Huang, Liyan Song, Ting Liu, Rongmin Yu: Structural characterization of a novel low-molecular-weight polysaccharide isolated from cultured fruiting bodies of Cordyceps militaris and its antioxidant, immunostimulatory and antitumor activities. Carbohydrate Polymers. 2014, 102: 288–296.

(21) Jian Xu, Zhiyan Chen, Liyan Song, Lili Chen, Jianhua Zhu, Shuangshuang Lv, Rongmin Yu: A new in vitro anti-tumor polypeptide isolated from Arca inflata. Marine Drugs. 2013, 11:4773–4787.

(22) Chunyan Yan, Yin Yin, Dawei Zhang, Wei Yang, Rongmin Yu: Structural characterization and in vitro antitumor activity of a novel polysaccharide from Taxus yunnanensis. Carbohydrate Polymers. 2013, 96: 389–395.

(23) Xianjing Hu, Liyan Song, Lijiao Huang, Qin Zheng, Rongmin Yu: Antitumor effect of a polypeptide fraction from Arca subcrenata in vitro and in vivo. Marine Drugs. 2012, 10: 2782–2794.

(24) Xuqiao Hu, Yuanyuan Huang, Quanfeng Dong, Liyan Song, Fei Yuan, Rongmin Yu: Structure characterization and antioxidant activity of a novel polysaccharide isolated from pulp tissues of Litchi chinensis. Journal of Agricultural and Food Chemistry. 2011, 59: 11548–11552.

(25) 于荣敏、黄璐琦  主编：《天然药物化学成分生物合成概论》，永利集团出版社，2011：广州.

(26) 于荣敏、张德志  主编：《天然药物化学成分波谱解析》，中国医药科技出版社，2008：北京.

(27) 于荣敏、赵昱  主编：《现代生物技术方法在中药现代化中的应用》，中国医药科技出版社，2005：北京.

联系方式：

电子邮箱：tyrm@jnu.edu.cn