理学博士，教授、博士生导师，教育部重大项目特聘教授、新世纪百千万人才工程国家级人选、全国创新争先奖获得者、广东省南粤百杰。1983年7月毕业于南京402永利集团官网(现中国药科大学)中药学专业，获学士学位；1983年8月−1988年10月在安徽中医药高等专科学校任教；1988年11月−1997年7月在中国药科大学天然药物化学教研室任教，先后任讲师、副教授；1997年8月−2001年10月在香港科技大学化学系学习，获博士学位；2001年12月起任中国药科大学教授、博士生导师；2002年8月−2015年11月先后担任永利集团中药及天然药物研究所常务副所长，中药系主任，402永利集团官网副经理、经理。2014年10月起任永利集团副董事长。

长期从事中药和天然药物活性成分、天然产物化学生物学、创新药物研发等研究工作。先后主持了国家重点研发计划、国家自然科学基金重点项目、国家自然科学基金-广东联合基金重点项目、国家重大科技专项和科技支撑计划、教育部重大项目创新团队、广东省珠江人才计划首批本土创新科研团队、广东省重点领域研发计划、广东省和广州市重大科技专项等科研项目40余项。已发表研究论文800余篇，其中在JACS、J Clin Invest、Angew Chem Int Ed、J Extracell Vesicels、Hepatology、Mol Psychiatry、STTT、Chem Sci、Org Lett、J Nat Prod等SCI收录杂志发表论文510余篇，先后6次被列入Elsevier中国高被引学者榜单，获授权国内外发明专利50余项，获一类和五类中药新药临床研究批件各1项；以第一完成人获国家科技进步奖二等奖1项、广东省科学技术奖一等奖3项，并获中国产学研合作创新成果一等奖2项、中国专利优秀奖1项；主编著作1部，参编著作12部；主要成果之一“中药和天然药物的三萜及其皂苷成分研究与应用”入选2017中国十大医学进展。讲授了多门本科生和研究生课程，培养硕士和博士研究生180余名。

现兼任国家药典委员会委员、中国药学会理事及广东省药学会副理事长、世界中联中药化学专业委员会副会长、中国药学会中药和天然药物专业委员会副主任委员、广东省学位委员会委员、广东省政协常委委员、九三学社中央委员及广东省委副主委，以及《现代中药研究与实践》杂志主编、Chemistry & Biodiversity和Journal of Asian Natural Products Research等10余种国内外专业学术期刊编委。获第二届全国创新争先奖、中国药学发展奖、国务院政府特殊津贴、广东省丁颖科技奖，并获全国模范教师、全国优秀科技工作者称号。

主要研究方向：

1. 中药及天然药物活性成分研究
2. 活性天然产物的化学生物学研究
3. 中药及天然药物来源的创新药物研究

代表性论文：

1. Huang M, Chen M, Qi M, Ye G, Pan J, Shi C, Yang Y, Zhao L, Mo X, Zhang Y, Li Y, Zhong J, Lu W, Li X, Zhang J, Lin J, Luo L, Liu T, Tang P M-K, Hong A, Cao Y*, Ye W*, Zhang D*. Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs. Journal of Extracellular Vesicles, 2021, 10, e12096. (IF: 25.841)

2. He QF, Wu ZL, Li L, Sun WY, Wang GY, Jiang RW, Hu LJ, Shi L, He RR, Wang Y*, Ye WC*. Discovery of neuritogenic Securinega alkaloids from Flueggea suffruticosa by a building-block-based molecular network strategy. Angewandte Chemie-International Edition, 2021, 60, 19609. (IF: 15.336)

3. Wu ZL, Zhao BX, Huang XJ, Tang GY, Shi L, Jiang RW, Liu X, Wang Y*, Ye WC*. Suffrutines A and B: a pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa. Angewandte Chemie, International Edition, 2014, 53, 5796−5799. (IF:12.959)

4. Cheng MJ, Zhong LP, Gu CC, Zhu XJ, Chen B, Liu JS, Wang L*, Ye WC*, Li C-C*. Chuang-Chuang Li. Asymmetric total synthesis of bufospirostenin A. Journal of the American Chemical Society, 2020,142, 12602−12607. (IF:15.419)

5. Ma N, Hu J, Zhang ZM, Liu WY, Huang MH, Fan YL, Yin XF, Wang J*, Ding K*, Ye WC*, Li ZQ*. 2H-azirine-based reagents for Chemoselective Bioconjugation at carboxyl residues inside live cells. Journal of the American Chemical Society, 2020,142, 6051−6059. (IF: 15.419)

6. Chen MF, Lei XP, Shi CZ, Huang MH, Li XB, Wu BJ, Li ZQ, Han WL, Du B, Hu JY, Nie QL, Mai WQ, Ma N, Xu NH, Zhang XY, Fan CL, Hong AH, Xia MH, Luo LP, Ma AD, Li HH, Yu Q, Chen HR*, Zhang DM*, Ye WC*. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. The Journal of Clinical Investigation, 2017, 127, 3689−3701. (IF:14.808)

7. Guo D, Peng Y, Wang L, Sun X, Wang X, Liang C, Yang X, Li S, Xu J, Ye WC*, Jiang B*, Shi L*. Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Molecular Psychiatry, 2021, 26, 1505–1519. (IF:15.992)

8. Qu C, He L, Yao N, Li J, Jiang Y, Li B, Peng S, Hu K, Chen D, Chen G, Huang W, Cao M, Fan J, Yuan Y, Ye W*, Hong J*. Myofibroblast-Specific Msi2 Knockout Inhibits Hepatocellular Carcinoma Progression in a Mouse Model. Hepatology, 2021, 74, 458–473. (IF: 17.425)

9. Yao N, Wang CR, Liu MQ, Li YJ, Chen WM, Li ZQ, Qi Q, Lu J-J, Fan CL, Chen MF, Qi M, Li XB, Hong J, Zhang DM*, Ye WC*. Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth. Signal Transduction and Targeted Therapy,2020,5, 214. (IF:18.187)

10. Cheng MJ, Cao JQ, Yang XY, Zhong LP, Hu LJ, Lu X, Hou BL, Hu YJ, Wang Y, You XF, Wang L*, Ye WC*, Li CC*. Catalytic asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B and callistrilones A, C, D, E. Chemical Science, 2017, 34, 2413−2421. (IF:9.852)

11. Lei XP, Chen MF, Huang MH, Li XB, Shi CZ, Zhang D, Luo LP, Zhang YW, Ma N, Chen HR, Liang HF, Ye WC*, Zhang DM*. Desacetylvinblastine monohydrazide disrupts tumor vessels by promoting VE-cadherin internalization. Theranostics, 2018, 8, 384−398. (IF:11.556)

12. Zhang DM, Xu HG, Wang L, Li YJ, Sun PH, Wu XM, Wang GJ, Chen WM, Ye WC*. Betulinic acid and its derivatives as potential antitumor agents. Medicinal Research Reviews, 2015, 35, 1127−1155. (IF:12.944)

13. Wu ZL, Huang XJ, Hu LJ, Zhang WY, Xie QJ, Jiang RW, Wang Y*, Ye WC*. Absolute configurations and stereochemical inversion mechanism of epimeric Securinega alkaloids from Flueggea suffruticosa. Organic Letters, 2020,22, 3673−3678. (IF: 6.005)

14. Gu JH, Wang WJ, Chen JZ, Liu JS, Li NP, Cheng MJ, Hu LJ, Li CC*, Ye WC*, Wang Lei*. Leptosperols A and B, two cinnamoylphloroglucinol-sesquiterpenoid hybrids from Leptospermum scoparium: structural elucidation and biomimetic synthesis. Organic Letters, 2020,22, 1796−1800. (IF: 6.005)

15. Cheng MJ, Yang XY, Cao JQ, Liu C, Zhong LP, Wang Y, You XF, Li CC*, Wang L*, Ye WC*. Isolation, structure elucidation, and total synthesis of myrtuspirone A from Myrtus communis. Organic Letters, 2019, 21, 1583−1587. (IF: 6.005)

16. Song JG, Su JC, Song QY, Huang RL, Tang W, Hu LJ, Huang XJ, Jiang RW, Li YL, Ye WC*, Wang Y*. Cleistocaltones A and B, antiviral phloroglucinol-terpenoid adducts from Cleistocalyx operculatus. Organic Letters, 2019, 21, 9579−9583. (IF: 6.005)

17. Wu ZL, Huang XJ, Xu MT, Ma X, Li L, Shi L, Wang WJ, Jiang RW, Ye WC*, Wang Y*. Flueggeacosines A–C, dimeric Securinine-type alkaloid analogues with neuronal differentiation activity from Flueggea suffruticosa. Organic Letters, 2018, 20, 7703−7707. (IF: 6.005)

18. He QF, Wu ZL, Huang XJ, Zhong YL, Li MM, Jiang RW, Li YL, Ye WC*, Wang Y*. Cajanusflavanols A-C, three pairs of flavonostilbene enantiomers from Cajanus cajan. Organic Letters, 2018, 20, 876−879. (IF: 6.005)

19. Zhang W, Xu W, Wang GY, Gong XY, Li NP, Wang L*, Ye WC*. Gelsekoumidines A and B: two pairs of Atropisomeric Bisindole alkaloids from the Roots of Gelsemium elegans. Organic Letters, 2017, 19, 5194−5197. (IF: 6.005)

20. Cao JQ, Huang XJ, Li YT, Wang Y, Wang L*, Jiang RW, Ye WC*. Callistrilones A and B, triketone-phloroglucinol-monoterpene hybrids with a new skeleton from Callistemon rigidus. Organic Letters, 2016, 18, 120−123. (IF: 6.005)

21. Liu C, Ang S, Huang XJ, Tian HY, Deng YY, Zhang DM, Wang Y, Ye WC*, Wang L*. Meroterpenoids with new skeletons from Myrtus communis and structure revision of myrtucommulone K. Organic Letters, 2016, 18, 4004−4007. (IF: 6.005)

22. Li XL, Zhao BX, Huang XJ, Zhang DM, Jiang RW, Li YJ, Jian YQ, Wang Y*, Li YL*, Ye WC*. (+)- and (-)- Cajanusine, a pair of new enantiomeric stilbene dimers with a new skeleton from the leaves of Cajanus cajan. Organic Letters, 2014, 16, 224−227. (IF: 6.005)

23. Zhao BX, Wang Y*, Zhang DM, Huang XQ, Bai LL, Yan Y, Chen JM, Lu TB, Wang YT, Zhang QW*, Ye WC*. Virosaines A and B, two new birdcage-shaped securinega alkaloids with an unprecedented skeleton from Flueggea virosa. Organic Letters, 2012, 14, 3096−3099. (IF: 6.005)

24. Shao M, Wang Y, Jian YQ, Huang XJ, Zhang DM, Tang QF, Jiang RW, Sun XG, Lv ZP, Zhang XQ, Ye WC*. Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava. Organic Letters, 2012, 14, 5262−5265. (IF: 6.005)

25. Wang CQ, Wang L, Fan CL, Zhang DM, Huang XJ, Jiang RW, Bai LL, Shi JM, Wang Y, Ye WC*. Ilelic Acids A and B, two unusual triterpenes with a seven-membered ring from Ilex latifolia. Organic Letters, 2012, 14, 4102−4105. (IF: 6.005)

26. Zhao BX, Wang Y, Zhang DM, Jiang RW, Wang GC, Shi JM, Huang XJ, Chen WM, Che CT, Ye WC*. Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa. Organic Letters, 2011, 13, 3888−3891. (IF: 6.005)

27. Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC*. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Organic Letters, 2010, 12, 5040−5043. (IF: 6.005)

28. Ma N, Yao YW, Zhao BX, Wang Y, Ye WC*, Jiang S*. Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine. Chemical Communications, 2014, 50, 9284−9287. (IF: 6.222)

29. Deng LJ, Wang LH, Peng CK, Li YB, Huang MH, Chen MF, Lei XP, Qi M, Cen Y, Ye WC*, Zhang DM*, Chen WM*. Fibroblast activation protein α activated tripeptide bufadienolide antitumor prodrug with reduced cardiotoxicity. Journal of Medicinal Chemistry, 2017, 60, 5320−5333. (IF: 7.446)

30. Liu JS, Zhang DM, Li Y, Chen WM, Ruan ZX, Deng LJ, Wang LW, Tian HY, Yiu A, Fan CL, Luo H, Liu SW, Wang Y, Xiao GK, Chen LX*, Ye WC*. Discovery of bufadienolides as a novel calss of CIC-3 chloride chanel activators with antitumor activities. Journal of Medicinal Chemistry, 2013, 56, 5734−5743. (IF: 7.446)

31. Luo SL, Hu LJ, Huang XJ, Su JC, Shao XH, Wang L, Xu HH, Li CC, Wang Y*,Ye WC*. Discovery and biomimetic synthesis of a phloroglucinol-terpene adduct collection from Baeckea frutescens and its biogenetic origin insight. Chemistry – A European Journal, 2020, 26, 11104−11108. (IF: 5.236)

32. Liu F, Tian H-Y, Huang X-L, Wang W-J, Li N-P, He J, Ye W-C*, Wang L*. Xanthchrysones A-C: rearranged phenylpropanoyl-phloroglucinol dimers with unusual skeletons from Xanthostemon chrysanthus. The Journal of Organic Chemistry 2019,84, 15355−15361. (IF: 4.354)

33. Liu H, Wu ZL, Huang XJ, Peng Y, Huang X, Shi L, Wang Y*, Ye WC*. Evaluation of diarylheptanoid-terpene adduct enantiomers from Alpinia officinarum for Neuroprotective Activities. Journal of Natural Products, 2018, 81, 162−170. (IF: 4.050)