申丽，工学博士，研究员，博士生导师，2020年广东省杰出青年基金获得者。2004年6月毕业于华东理工大学应用化学专业，获学士学位；2010年3月，获华东理工大学应用化学专业博士学位；同年4月前往夏威夷大学希洛分校402永利集团官网从事博士后研究。2013年1月入职402永利集团官网。以第一/（共）通讯作者在Angew. Chem. Int. Ed.，Chem. Sci., Org. Lett., Green Chem.等杂志发表SCI论文37篇；获授权发明专利1项；主持国家自然科学基金项目2项、广东省自然科学基金项目1项、广州市科技计划项目1项；作为骨干成员参与NSFC-广东联合基金重点项目和NSFC-以色列基金会国际合作研究项目等。担任国家自然科学基金评审专家，美国化学会，北美植物化学会会员，Chemistry-Asian J., Bioorg. Med. Chem.等多个SCI期刊审稿人。

研究方向：

1. 红树植物活性天然产物的发现，仿生合成与结构优化

2. 海洋甲藻中超级碳链化合物的发现与绝对构型确立

主持的科研项目：

1. 国家自然科学基金面上项目（31770377），针对三阴性乳腺癌的红树植物新奇柠檬苦素挖掘、结构多样性导向合成与体内外活性评价（2018.01-2021.12，60万元）

2. 国家自然科学基金青年科学基金项目（81302693），基于氧化偶联机制的新奇柠檬苦素二聚体的半合成与功能探究（2014.01-2016.12，24万元）

3. 广东省杰出青年基金（2020B1515020056），红树植物萜类新药先导物的高效挖掘、仿生合成与结构优化（2019.10-2023.09，100万元）

4. 广州市科技计划项目-珠江科技新星专项（201506010023），红树植物来源新型细菌生物被膜小分子抑制剂的结构优化与作用机制研究（2015.04-2018.03，30万元）

5. 永利集团科研培育与创新基金跃升计划项目（21617474），红树植物抗肿瘤新萜类化合物的发现、仿生合成与结构优化（2017.01-2018.12，12万元）

近五年的代表性论文：

1. Discovery of benthol A and its challenging stereochemical assignment: opening up a new window for skeletal diversity of super-carbon-chain compounds.Zhong-Ping Jiang, Shi-Hao Sun, Yi Yu, Attila Mándi, Jiao-Yang Luo, Mei-Hua Yang, Tibor Kurtán,* Li Shen,* and Jun Wu.* Chemical Science, 2021, online, https://doi.org/10.1039/D1SC02810C.

2. Determination of the Absolute Configuration of Super-Carbon-Chain Compounds by a Combined Chemical, Spectroscopic, and Computational Approach: Gibbosols A and B.Wan-Shan Li, Ren-Jie Yan, Yi Yu, Zhi Shi, Attila Mándi,Li Shen,* Tibor Kurtán,* and Jun Wu*. Angewandte Chemie International Edition, 2020, 59, 13028.

3. A water-soluble 5/14-carbobicyclic steroid with a trans-9,11-epoxy ring from the marine dinoflagellate Amphidinium gibbosum: insights into late-stage diversification of steroids.Li Shen,* Wan-Shan Li, Yi Yu, Shi-Hao Sun, and Jun Wu.*Organic Letters,2021, 23, 837.

4. Discovery of Thai mangrove tetranortriterpenoids as agonists of human pregnane–X–receptor and inhibitors against human carboxylesterase 2. Yan-Xia Ren,^# Xiao-Peng Zou,^# Wan-Shan Li, Jun Wu*, and Li Shen.* Bioorganic Chemistry. 2021, 107, 104599.

5. Granatripodins A–B, limonoids featuring a Tricyclo[3.3.1.0^2,8]nonane motif: Absolute configuration and agonistic effects on human pregnane–X–receptor.Li Shen,*^# Xiao-Peng Zou,^# Wan-Shan Li, Attila Mándi, Tibor Kurtán,* and Jun Wu.* Bioorganic Chemistry. 2021, 111, 104888.

6. Krishnolides E–K: New limonoids from the Krishna mangrove Xylocarpus moluccensis. Chun-Liu He, Wan-Shan Li, Jun Wu,* and Li Shen.* Fitoterapia, 2021, 150, 104835.

7. Agallolides A-M, including two rearranged ent-atisanes featuring a bicyclo[3.2.1]octane motif, from the Chinese Excoecaria agallocha.Zhong-Ping Jiang, Yi Yu, Li Shen*. Bioorganic Chemistry. 2020, 104, 104206.

8. Twenty-five limonoids from the Hainan mangrove, Xylocarpus granatum. Jia-Cheng Zhang,^# Qi Liao, ^#Li Shen,* and Jun Wu*. Bioorganic Chemistry. 2020, 100, 103903.

9. Xylomolones A-D from the Thai mangrove Xylocarpus moluccensis: assignment of absolute stereostructures and unveiling a convergent strategy for limonoid biosynthesis. Wan-Shan Li, Attila Mándi, Jun-Jun Liu, Li Shen,* Tibor Kurtán,* and Jun Wu*. The Journal of Organic Chemistry. 2019, 84, 2596.

10. Ent-kauranes from the Chinese Excoecaria agallocha L. and NF-κB inhibitory activity. Zhong-Ping Jiang, Bin-Hua Zou, Xiao-Juan Li, Jun-Jun Liu, Li Shen,* Jun Wu.*Fitoterapia, 2019, 133, 159.

11. Tagalide A and Tagalol A, Naturally Occurring 5/6/6/6- and 5/6/6-Fused Cyclic Dolabrane-Type Diterpenes: A New Insight into Anti-Breast Cancer Activity of the Dolabrane Scaffold. Xiao-Hui Zhang,^# Yang Yang,^# Jun-Jun Liu, Li Shen,* Zhi Shi* and Jun Wu*. Organic Chemistry Frontiers, 2018, 5, 1176.

12. Scaffold diversity-oriented synthesis of limonoid dimers: discovery of an axially chiral agent with in vivo anti-breast cancer activity. Wan-shan Li,^# Yang Yang,^# Jun-Jun Liu, Li Shen,* Zhi Shi* and Jun Wu*.Organic Chemistry Frontiers, 2018, 5, 1079.

13. Twenty-Nine New Limonoids with Skeletal Diversity from the Mangrove Plant, Xylocarpus moluccensis. Jian-Zhi Zhang, Wan-Shan Li, Yi-Guo Dai, Li Shen*, and Jun Wu*. Marine Drugs, 2018, 16, 38.

14. Limonoids Containing a C1–O–C29 Moiety: Isolation, Structural Modification, and Antiviral Activity. Jing-Ling Ren, Xiao-Peng Zou, Wan-Shan Li, Li Shen*, and Jun Wu*. Marine Drugs,2018, 16, 434.

15. Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor. Zhong-Ping Jiang, Zhi-Lin Luan, Ruo-Xi Liu, Qun Zhang, Xiao-Chi Ma, Li Shen*, Jun Wu*. Marine Drugs, 2018, 16, 488.

16. Four new diterpenes from the mangrove Ceriops tagal and structure revision of four dolabranes with a 4,18-epoxy group. Xiao-Hui Zhang, Wan-Shan Li, Li Shen,* Jun Wu.*Fitoterapia, 2018, 124, 1.

17. Krishnagranatins A–I: New limonoids from the mangrove, Xylocarpus granatum, and NF-κB inhibitory activity. Ruo-Xi Liu, Qi Liao, Li Shen*, and Jun Wu*. Fitoterapia, 2018,131, 96.

18. New 30-ketophragmalins with anti-breast cancer activity against MDA-MB-453 cells from the Godavari mangrove, Xylocarpus moluccensis (Lam.) M. Roem. Min Zhang, Zhi Shi, Jun-Jun Liu, Li Shen*, Jun Wu*.Phytochemistry Letters, 2018, 26, 143.

19. Highly selective reduction of nitrobenzenes to azoxybenzenes with a copper catalyst. Zhi-Chao Chen, Ya-Tao Qiu, Xiao-Xing Wu, Yong Ni, Li Shen*, Jun Wu*, and Sheng Jiang*. Tetrahedron Letters, 2018, 59(14), 1382.

20. Krishnadimer A, an Axially Chiral Non-Biaryl Natural Product: Discovery and Biomimetic Synthesis. Wan-Shan Li,Jun Wu, Jun Li, Tirumani Satyanandamurty,Li Shen,*and Gerhard Bringmann*.Organic Letters,2017, 19(1), 182.

21. Krishnolides A-D: New 2-Ketokhayanolides from the Krishna Mangrove, Xylocarpus moluccensis. Qun Zhang, Tirumani Satyanandamurty, Li Shen,* and Jun Wu.*Marine Drugs,2017, 15, 333.

22. Sundarbanxylogranins A−E, Five New Limonoids from the Sundarban Mangrove, Xylocarpus granatum. Yi-Guo Dai, Jun Wu, Krishna Pillai Padmakumar, Li Shen*.Fitoterapia, 2017, 122, 85.

23. Trangmolins A–F with an Unprecedented Structural Plasticity of the Rings A and B: New Insight into Limonoid Biosynthesis. Wan-Shan Li, Li Shen*, Torsten Bruhn, Patchara Pedpradab, Jun Wu*, and Gerhard Bringmann*. Chemistry-A European Journal, 2016, 22, 11719.

24. Thaixylomolins O-R: four new limonoids from the Trang mangrove, Xylocarpus moluccensis. Yi-Guo Dai, Wan-Shan Li, Patchara Pedpradab, Jun-Jun Liu, Jun Wu, andLi Shen*.RSC advance, 2016, 6, 85978.

25. A tirucallane and two pairs of tetranortriterpene 23-epimers from the Thai mangrove Xylocarpus moluccensis. Kai Niu,Li Shen*, and Jun Wu*.Journal of Asian Natural Products Research, 2016, 18, 1, 36.