孙晗笑，女，博士，教授，现任基因组药物研究所所长、生物制药系主任、药物毒理学教研室主任。先后主持国家863计划项目、国家自然科学基金、国家国际合作项目、省自然科学基金等科研项目20余项，发表科研论文近100篇，近五年发表SCI论文20余篇。申请专利30余项。2006年、2007年分别以第一获奖人获得中华医学奖三等奖以及广东省科学技术奖二等奖。主编出版的《转基因技术理论与应用》获国家优秀科技图书二等奖。2007年获中华全国归国华侨“科技创新人才奖”。

回国后研发的重组vMIP已获生物I类新药临床批文，并主持完成该新药的I期和IIa期临床研究。近年的研究主要集中在sir2家族基因的抗衰老研究，目前该研究项目已和公司合作进行生物I类新药研发。该项目的双基因Rt-sirt2/4-Tet-nap质粒DNA预期可用于衰老相关疾病治疗。

教育经历：

1992/09-1995/07，中国医学科学院肿瘤研究所与河南医大联合培养，博士

导师：程书均院士

1986/09-1989/07，河南医大基础学院病理学教研室，癌前期研究室，硕士

导师：祝庆蕃教授

1979/09-1984/07，河南医科大学医疗系，学士

科研与学术工作经历：

2002/10-至今，永利集团，402永利集团官网基因组药物研究所,所长，教授

1998/09-2002/09，永利集团，医学院病理教研室，副教授

1996/09-1998/08，加拿大蒙特利尔大学，生化系，博士后

合作导师：Tony Ankley 教授

1995/08-1996/08，河南医科大学，基础学院，博士后

合作导师：沈琼教授

1989/08-1992/08，河南医科大学，基础学院，讲师

1984/08-1986/08，河南医科大学，基础学院，助教

代表性学术论文情况：

1.         Yuzhe Wang, Shiyu Li, Mengge Liu, Jiajia Wang, Zhengbin Fei, Feng Wang, Zhenyou Jiang, Wenhua Huang, Hanxiao Sun^#. Rhodosporidium toruloides sir2-like genes remodelled the mitochondrial network to improve the phenotypes of ageing cells. Free Radical Biology and Medicine, 2019, 134:64-75. https://doi.org/10.1016/j.freeradbiomed.2018.12.036. (二区 IF: 6.020)

2.         Shiyu Li, Zhengbin Fei, Zhenrui Xu, Jiajia Wang, Zhenyou Jiang, Yajie Xie, Yuzhe Wang, Wenhua Huang, Hanxiao Sun^#. Enterococcus faecalis sir2-like gene enhances aerobic metabolism of themselves and mitochondrial respiration of mammal cells to bring about improving metabolic syndrome through the PGC-1α pathway. Journal of Tissue Engineering and Regenerative Medicine, 2019, 13:143–155. https://doi.org/10.1002/term.2775. (二区IF: 4.089)

3.         Zhengbin Fei, Shiyu Li, Jiajia Wang, Yuzhe Wang, Zhenyou Jiang, Wenhua Huang, Hanxiao Sun^#. Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo. Drug Delivery, 2019, 26:1, 51-62. DOI: 10.1080/10717544.2018.1551439. (一区IF: 3.092)

4.         Mengge Liu, Shiyu Li, Qian Zhang, Zhenrui Xu, Jiajia Wang, Hanxiao Sun^#. Oral engineered Bifidobacterium longum, expressing rhMnSOD to suppress experimental colitis[J]. International Immunopharmacology, 2018, 57:25. (IF 3.118)

5.         Qing Guo, Shiyu Li, Yajie Xie, Qian Zhang, Mengge Liu, Zhenrui Xu, Hanxiao Sun*, Yan Yang. The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (σH) and FOXO3a in Bifidobacterium longum and HEK293T cells respectively[J]. Free Radical Biology and Medicine, 2017, 108:929–939. (二区 IF: 6.020)

6.         Wei P, Yang Y, Liu Z, Huang J, Gong Y, Sun HX*. Oral Bifidobacterium longum expressing alpha-melanocyte-stimulating hormone to fight experimental colitis [J]. Drug delivery, 2016,23(6):2058-2064. (一区 IF: 3.092)

7.         Ding Q, Li S, Jiang Z, Yang Y, Yu H, Wei P, Liu Z, Huang J, Gong Y, Sun H*. HIV-1 Coreceptor CXCR4 Antagonists Promote Clonal Expansion of Viral Epitope-Specific CD8+ T Cells During Acute SIV Infection in Rhesus Monkeys In Vivo[J]. Journal of Acquired Immune Deficiency Syndromes, 2015, 69(2):145-153. (二区IF: 4.116)

8.         Liu M, Li S, Zhang Q, Xu Z, Wang J, Sun H. Oral Bifidobacterium longum expressing GLP-2 improves nutrient assimilation and nutritional homeostasis in mice. Journal of Microbiological Methods, 2018, 145:87-92. (四区IF 1.701)

9.         Zhenrui Xu, Shiyu Li, Mengge Liu, Qian Zhang, Jiajia Wang, Yuzhe Wang, Zhengbin Fei, Hanxiao Sun. Bifidobacterium longum as an Orally Administered Carrier of Human-Beta-Defensin-2 to Treat Colonic Crohn’s Disease[J], Journal of Pharmaceutical and Biomedical Sciences, 2018, 48-55.

10.     Han J F , Qiu Y , Yu J Y , Hanxiao Sun *et al. Immunization with truncated envelope protein of Zika virus induces protective immune response in mice[J]. Scientific Reports, 2017, 7(1):10047.（IF：4.36）

11.     Guo Q, Li S, Xie Y, et al. Bifidobacterium Longum as an Orally Administered Carrier of LL-37 to Treat Bacterial Diarrhea[J]. Journal of Pharmaceutical and Biomedical Sciences, 2017, 7(6).

12.     Xie Y, Guo Q, Li S, Liu M, Zhang Q, Xu Z,Sun H, Anti-inflammatory properties of Bifidobacterium longum expressing human manganese superoxide dismutase using the TNBS-induced rats model of colitis[J]. Journal of microbiology and biotechnology, 2017. (四区 IF1.650)

13.     Huang J, Liu Z, Li S, Xu B, Gong Y, Yang Y, Sun H, Isolation and engineering of plant growth promoting rhizobacteria Pseudomonas aeruginosa for enhanced cadmium bioremediation[J]. Journal of General & Applied Microbiology, 2016, 62(5):258-265. (四区 IF0.789)

14.     Liu ZB, Huang JL, Ding Q, Yang Y and Sun HX*, Analysis of contributions of herpes simplex virus type 1 UL43 protein to induction of cell-cell fusion[J], Tropical Journal of Pharmaceutical Research.2016.15(6):1137-1144. (四区 IF0.444)

15.     Gong Y, Li T, Li S, Jiang Z, Yang Y, Huang J, Liu Z, Sun H, Achieving High Yield of Lactic Acid for Antimicrobial Characterization in Cephalosporin-Resistant Lactobacillus by the Co-Expression of the osphofructokinase and Glucokinase[J], Journal of Microbiology and Biotechnology, 2016, 26(6):1148-1161. (四区 IF1.650)

16.     Wei P, Yang Y, Liu Z, Huang J, Gong Y, Sun HX*. Oral Bifidobacterium longum expressing alpha-melanocyte-stimulating hormone to fight experimental colitis [J], Drug delivery, 2016,23(6),2058-2064. (二区 IF3.095)

17.     Yang Y, Sun HX*, Li X, Ding Q, Wei P, Zhou J. Transforming Growth Factor Beta-Induced Is Essential for Endotoxin Tolerance Induced by a Low Dose of Lipopolysaccharide in Human Peripheral Blood Mononuclear Cells [J], Iranian Journal of Allergy, Asthma and Immunology, 2015, 14(3):321-330. (4区 IF1.049)

18.     Ding Q, Li S, Jiang Z, Yang Y, Yu H, Wei P, Liu Z, Huang J, Gong Y, Sun H*, HIV-1 Coreceptor CXCR4 Antagonists Promote Clonal Expansion of Viral Epitope-Specific CD8+ T Cells During Acute SIV Infection in Rhesus Monkeys In Vivo [J], JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015, 69(2): 145-153. (二区 IF4.116)

19.     Wei PJ, Yang Y, Li TY, Ding Q, Sun HX*. A engineered Bifidobacterium longum secreting a bioative penetratin-Glucagon-like peptide 1 fusion protein enhances Glucagon-like peptide 1 absorption in the intestine [J], Journal of microbiology and biotechnology, 2015. (四区 IF1.650)

20.     Mo XM, Sun HX*, The Anti-inflammatory Effect of the CXCR4 Antagonist-N15P Peptide and Its Modulation on Inflammation-Associated Mediators in LPS-Induced PBMC[J], Inflammation, 2015, 38(3):1374-83. (三区 IF2.884)

21.     Xu B, Tian P, An GJ, Liu S, Li XY, Sun HX*, Zhou Jing-Gung, Ding Qing, Wei Pi-Jin, Synthetic Polypeptide Derived from Viral Macrophage Inflammatory Protein II Inhibit VEGF Production of Human Glioma U87 Cells through SDF-1 alpha/CXCR4-Mediated AKT Signaling Pathway, Trop J Pharm Res, 2014, 13(8): 1327-1332. (四区 IF0.444)

22.     Tian Peng, Xu Bo, Sun HX*, Li Xiuying, Li Zhi, Wei Pijin, Isolation and gut microbiota modulation of antibiotic-resistant probiotics from human feces, Diagnostic Microbiology and Infectious Disease, 2014, 79(4): 405-412. (三区 IF2.341)

23.     Liu S, Ding Q, Wei PJ, Sun HX*, Li XY, An GJ, Yang Y, Zhou JG, Screening and mechanism of antagonist peptide for CC chemokine receptor 1 (CCR1) derived from viral macrophage inflammatory protein II, Trop J Pharm Res, 2014, 13: 697. (四区 IF0.444)

24.     An GJ, Li XY, Sun HX*, Liu S, Zhou JG, Ding Q, Wei PJ, Zhang G, Synthetic polypeptide derived from viral macrophage inflammatory protein II inhibit the uninfected CD4+ T cells apoptosis induced by HIV-1 extracellular nef, Trop J Pharm Res, 2014, 13: 683. (四区 IF0.444)

25.     Shi W, Xu B, Tian P, Li X, Sun H, A trapping ligand antagonist peptide H22-LP inhibition of human cytomegalovirus infection[J], Journal of Microbiology, Immunology and Infection, 2016, 49(2):189-195. (三区 IF2.094)

26.     Zhang Z, Huang L, Wu Q, Yang E, Zhang G, Sun H, Wang F, A recombinant trans-membrane protein hMnSOD-R9 inhibits the proliferation of cervical cancer cells in vitro[J], Molecular & Cellular Biochemistry, 2014, 385(1-2):79-86.(三区 IF2.561)

27.     Shi WJ, Sun HX*, Mo XM, Li SY, Li XY, Zhang G, Liu HA, Development of a broad-spectrum antiviral agent with activity against herpesvirus replication and gene expression, Trop J Pharm Res, 2013, 12(4):541-547. (四区 IF0.444)

28.       Su Yan，Sun HX*，Li XY，Mo XM，Zhang G , Screening for a peptide that inhibits expression of a broad-spectrum of chemokines using models of endotoxin tolerance and LPS-induced pro-inflammation, Progress in Biochemistry and Biophysics, 2013, 40: 461-470. (四区 IF0.288)

29.     Zhao YX, Sun HX*, Li XY, Mo XM, Zhang G, Anti-HIV Effect of Liposomes Bearing CXCR4 Receptor Antagonist N15P, Tropical Journal of Pharmaceutical Research, 2013, 12(4): 503-509. (四区 IF0.444)

30.     Li Z, Sun HX*, Mo XM, Li XY, Xu B, Tian P, Overexpression of malic enzyme (ME) of Mucor circinelloides improved lipid accumulation in engineered Rhodotorula glutinis, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2013, 97(11): 4927-4936. (二区 IF3.340)

31.     Wang F, Li XY, Mo XM, Zhang G,Sun HX, A biologically active vMIP-II-IgG3-TfN fusion protein, secreted from methylotrophic yeast Pichia pastoris[J], Protein Expression and Purification, 2013, 87(1):47-54. (四区 IF1.338)

32.     Liu HA, Sun HX*, Mo XM, Li SY, Li XY, Zhang G, Li L, Anti-HCMV and KSHV effect of a trapping ligand antagonist for Herpesvirus-encoded GPCR, Indian J Exp Biol, 2012, 50:313. (4区 IF1.475)

33.     Liu HA, Sun HX*, Li L, Mo XM, Li XY and Zhang G, Screening and mechanism of trapping ligand antagonist peptide for chemokine receptor US28 of human cytomegalovirus, Trop J Pharm Res, 2012, 11(2): 193-200. (四区 IF0.444)

34.     Yang Y, Sun H*, Mo X, et al. Prediction of novel genes associated with negative regulators of toll-like receptors-induced inflammation based on endotoxin tolerance.[J]. Inflammation, 2012, 35(6):1889-1899. (三区 IF2.884)