李正球，研究员，博士生导师。2010年毕业于中科院广州化学研究所获理学博士学位；2010年至2015年新加坡国立大学从事博士后研究工作。2015年9月加入402永利集团官网，从事教学科研工作。

主要围绕化学蛋白质组学技术开展创新药物发现研究，针对未满足临床需求的重大疾病开展靶标发现与新型先导化合物构建工作。承担国家重点研发计划子课题、国家自然科学基金、广东省杰出青年基金等项目。获得第二十一届中国药学会-施维雅青年药物化学奖。目前已在J. Am. Chem. Soc， Angew. Chem. Int. Ed., J. Med. Chem等顶级权威期刊发表SCI论文40余篇，申请发明专利十余项。

代表性论文：

1. Ma, N.; Hu, J.; Zhang, Z. M.; Liu,W.; Huang, M.; Fan, Y.; Yin,X.; Wang,J.;* Ding,K.;* Ye,W.-C.;*Li Z.*2H Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells J. Am. Chem. Soc.2020, 142, 6051-6059.

2. Zhu D.;Guo, H.;Chang, Y.; Ni Y.; Li L.; Zhang, Z-M.; Hao, P.;* Xu, Y.; Ding K.;* and Li Z.*. Cell- and Tissue-based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin. Angew. Chem. Int. Ed.2018,57, 9284 –9289.

3. Cheng, K.; Lee, J. S.; Hao, P.; Yao, S. Q.; Ding, K.;*Li, Z.*Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.Angew. Chem. Int. Ed.2017, 56，15044-15048.

4. Fan, Y.; Si, H.; Zhang, Z.; Zhong, L.; Sun, H.; Zhu, C.; Yin, Z.;Li, H.; Tang, G.; Yao, Shao Q.; Sun, P.;* Zhang, Z.-M.;* Ding, K.;* Li, Z.* Novel Electrophilic Warhead Targeting a Triple-Negative BreastCancer Driver in Live Cells Revealed by “Inverse Drug Discovery”.J. Med. Chem. 2021.

5. Li, Z.; Li, L.; Qian, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J. S.;Yao, S. Q.*Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications.Angew. Chem. Int. Ed.2016,55, 2002-2006.

6. Li, Z.;Wang, D.;Li L.;Pan, S.; Na, Z.; Tan, C. Y. J.;Yao, S. Q.*.'Minimalist' Cyclopropene-Containing Photo-Cross-Linkers Suitable for Affinity-Based Protein Labeling and Live-Cell Imaging. J. Am. Chem. Soc. 2014, 136, 9990-9998.

7. Li, Z.; Hao, P.; Li, L.; Tan, C. Y. J.; Cheng, X.; Chen, G. Y. J.; Sze, S. K.; Shen, H.-M.; Yao, S. Q.*. Design and Synthesis of “Minimalist”Terminal Alkyne-Containing Diazirine Photo-Cross-Linkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling. Angew. Chem. Int. Ed.2013, 52, 8551-8556.

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