王永恒，男，博士，研究员，硕士生导师，广东省杰青。2008年毕业于西北农林科技大学理学院，应用化学专业，获学士学位。2011年毕业于兰州大学化学化工学院，有机化学专业，获硕士学位。2015年毕业于厦门大学化学化工学院，理论与计算化学专业，获博士学位。2015年11月进入中山大学药学从事博士后工作，并于2017年12月被聘为“特聘研究员”。2019年3月以第四层次“人才引进”进入402永利集团官网，聘为“绿色通道副高”，2021年11月获评“广东省杰出青年”，2022年10月获评“正高”职称。现主持国家自然科学基金青年基金和面上项目各1项，国家重点研发计划子课题1项，省部级人才项目1项。在Nat. Catal., J. Am. Chem. Soc., ACS Catal., Chem. Comm.等著名期刊上发表SCI论文多篇。

研究方向：

生物体系理论计算与模拟、有机反应机理研究、有机合成

项目经费：

5．广东省杰出青年项目：四环/五环三萜环化酶催化与调控机制系统性研究及其理性改造，100万，2022.3-2025.12

4．国家自然科学基金面上项目：真菌Fusicoccane型萜类环化酶催化机制系统性研究及其理性改造，58万，2021.1-2024.12

3. 国家重点研发计划：《抗肿瘤、抗感染等活性天然产物的多方位发掘和激活》子课题，30万，2019.7-2024.6

2.永利集团人才引进科研启动经费，50万，2019.3-2025.2

1.国家自然科学基金青年基金项目：倍半萜合酶FSTS/SDS催化机制及其化学多样性调控研究，25万，2019.1-2021.12

学术论文( ^#:共同第一作者，*：通讯作者)：

25．Wang, Y.-H.^#; Xu, H.^#; Zhou, J.^#; Chen, X.; Zhuang, Y.; Liu, W.; Celik, E.; Chen, G.; Hu, D.; Gao, H.; Wu, R.*; Sun, P.*; Dickschat, JS.* Nat. Catal.2022, 5, 128-135 (IF=41.813).

24． Lin,F.-L^.#; Lauterbach, L^.#; Zou, J^.#; Wang, Y.-H.; Lv, J.-M.; Chen,G.-D.; Hu, D.*; Gao, H.*; Yao, X.-S. Dickschat, J. S.* Mechanistic Characterization of the Fusicoccane-Type Diter-pene Synthase for Myrothec-15(17)-en-7-ol. ACS Catal. 2020, 10, 4306−4312. (IF=12.221)

23．Diao, H.^#; Chen, N.^#; Wang, K.; Zhang, F.; Wang, Y.-H.*; Wu, R.*, Biosynthetic Mechanism of Lanosterol: A Completed Story. ACS Catal. 2020, 10, 2157-2168. (IF=12.221)

22．Wang, H.;  Wang, Y.-H.^#;  Liu, S.;  Mai, Y.;  Zong, X.;  Gao, H.;  Hu, R.; Jiang, X.; Yeung, Y.-Y., Enantioselective Fluorocyclizations Mediated by Amino-Acid-Derived Phthalazine. Adv. Syn. Catal. 2019, 361 (23), 5334-5339. (IF=5.837,)

21．Wang, Y.-H.; Zhang, F.; Diao, H.; Wu, R.*, Covalent Inhibition Mechanism of Antidiabetic Drugs—Vildagliptin vs Saxagliptin. ACS Catal. 2019, 9, 2292-2302. (IF=12.221,)

20．Kang, Z.; Wang, Y.-H.^#; Zhang, D.; Wu R.; Xu X.*; Hu, W.*, Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate. J. Am. Chem. Soc.2019, 141, 1473-1478. (IF=14.695)

19．Wang, Y.-H.; Wu, A.; Tan, K.; Lu, X. Metal-Catalyzed Alkyne Oxidation/C-H Functionalization: Effects of Oxidant, Temperature and Metal Catalyst on Chemoselectivity. J. Comput. Chem.2019, 40, 1038-1044. (IF=3.221, 中科院三区)

18．Long, L.; Wang, Y.-H.^#; Zhuo, J.-X.; Tu Z.-C.; Wu R.; Yan M.; Liu Q.; Lu G. Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors. Eur. J. Med. Chem..2018, 157, 1361-1375. (IF=4.846)

17．Wang, Y.-H.; Zhang, F.; Zhou, J.; Xie, H.; Wu, R.*, Reply to Comment on “Substrate Folding Modes in Trichodiene Synthase: A Determinant of Chemo- and Stereoselectivity”. ACS Catal. 2018, 8, 1363-1370. (IF=12.221)

16．Wang, Y.-H.; Xie, H.; Zhou, J.; Zhang, F.; Wu, R.*, Substrate Folding Modes in Trichodiene Synthase: A Determinant of Chemo- and Stereoselectivity. ACS Catal. 2017, 7, 5841-5846 (IF=12.221)

15．Li, J.-M.; Wang, Y.-H.^#; Yu, Y.; Wu, R.-B.; Weng, J.*; Lu, G.*, Copper-Catalyzed Remote C-H Functionalizations of Naphthylamides through a Coordinating Activation Strategy and Single-Electron-Transfer (SET) Mechanism. ACS Catal. 2017, 7 (4), 2661-2667. (IF=12.221,)

14．Luo, G.-G.*(通讯); Wang, Y.-H.^#; Wang, J.-H.; Wu, J.-H.; Wu, R.-B., A square-planar nickel dithiolate complex as an efficient molecular catalyst for the electro- and photoreduction of protons. Chem. Comm.2017, 53 (52), 7007-7010. (IF=6.290, 中科院一区)

13．Zhao, Y.; Wang Y.-H.^#; Lin, J.; Wu Q.; Wu, S.; Hou W.; Wu, R.; Luo, G-G.* New tricks for an old dog: Visible light-driven hydrogen production from water catalyzed by fac- and mer- geometrical isomers of tris(thiosemicarbazide) cobalt(III), Chin. J. Catal.2018, 39, 517-529. (IF=3.525, 中科院二区)

12．Zhou, S.-W.; Jiang, F.; Yu, Y.; Huang, X.-Y.*; Wang, Y.-H.*; Luo, S.-L.* Atropisomerism of a Podophyllotoxin Derivative: Experimental and Computational Study. Nature Product communications2018, 13 (6), 735-736. (IF=0.809)

11．Zhang, F.; Wang, Y.-H.; Tang, X.; Wu, R. Catalytic promiscuity of the non-native FPP substrate in the TEAS enzyme: non-negligible flexibility of the carbocation intermediate. Phys. Chem. Chem. Phys.2018, 20 (22), 15061-15073. (IF=3.906, 中科院二区)

10．Zheng, Z.;  Zhang, M.;  Wang, Y.-H;  Ma, R.;  Guo, C.;  Feng, L.;  Wu, J.;  Yao, H.; Lin, D., Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease. Scientific Reports2018, 8.

9.Fan, F.; Chen, N.; Wang, Y.-H.; Wu, R.; Cao, Z., QM/MM and MM MD Simulations on the Pyrimidine-Specific Nucleoside Hydrolase: A Comprehensive Understanding of Enzymatic Hydrolysis of Uridine. J. Phys. Chem. B2018, 122 (3), 1121-1131. (IF=3.146)

8.Cheng, C.; Diao, H.; Zhang, F.; Wang, Y.-H.; Wang, K.; Wu, R., Deciphering the mechanisms of selective inhibition for the tandem BD1/BD2 in the BET-bromodomain family. Phys. Chem. Chem. Phys.2017, 19 (35), 23934-23941. (IF=3.906)

7.Zhu, C.^#; Yang, C.^#; Wang, Y.-H; Lin, G.; Yang, Y.; Wang, X.; Zhu, J.; Chen, X.; Lu, X.*; Liu, G.*; Xia, H.*, CCCCC pentadentate chelates with planar Mobius aromaticity and unique properties. Sci. Adv.2016, 2 (8). (IF=11.511)

6.Zhu, L.; Xiong, P.; Mao, Z.-Y.; Wang, Y.-H.; Yan, X.; Lu, X.; Xu, H.-C.*, Electrocatalytic Generation of Amidyl Radicals for Olefin Hydroamidation: Use of Solvent Effects to Enable Anilide Oxidation. Angew. Chem., Int. Ed. 2016, 55 (6), 2226-2229. (IF=12.102,)

5.Shu, C.; Wang, Y.-H.; Shen, C.-H.; Ruan, P.-P.; Lu, X.*; Ye, L.-W.*, Gold-Catalyzed Intermolecular Ynamide Amination-Initiated Aza-Nazarov Cyclization: Access to Functionalized 2-Aminopyrroles. Org. Lett.2016, 18 (13), 3254-3257. (IF=6.492)

4.Shu, C.; Shen, C.-H.; Wang, Y.-H.; Li, L.; Li, T.; Lu, X.*; Ye, L.-W.*, Synthesis of 2-Aza-1,3-butadienes through Gold-Catalyzed Intermolecular Ynamide Amination/C-H Functionalization. Org. Lett. 2016, 18 (18), 4630-4633. (IF=6.492)

3.Luo, G.-G.*; Lu, H.; Wang, Y.-H.; Dong, J.; Zhao, Y.; Wu, R.-B., A D-pi-A-pi-A metal-free organic dye with improved efficiency for the application of solar energy conversion. Dyes and Pigments2016, 134, 498-505. (IF=3.767)

2.Shu, C.; Wang, Y.-H.; Zhou, B.; Li, X.-L.; Ping, Y.-F. Lu, X * and Ye, L.-W. * Generation of α-Imino Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides. J. Am. Chem. Soc.2015, 137, 9567–9570. (IF=14.357, 中科院一区)

1.Li, L.^#; Zhou, B.^#; Wang, Y.-H.; Shu, C.; Pan, Y.-F.; Lu, X.*and Ye, L.-W.* Zinc-Catalyzed Alkyne Oxidation/C-H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines. Angew. Chem., Int. Ed. 2015, 54, 8245-8249. (IF=12.102)

邮箱：yhwang@jnu.edu.cn