李怡芳，402永利集团官网教授、博士生导师，永利集团广东省疾病易感性及中医药研发工程技术研究中心副主任，兼任Acta Pharm Sin B、Chin J Nat Med、Trad Med Res期刊青年编委等社会职务。

入选国家教育部重大人才项目青年学者、广东省自然科学基金杰出青年、广州市珠江科技新星等人才项目。主要从事免疫分子机制研究、免疫药理学、中药抗感染药理研究。相关研究获得国家自然科学基金、广东省自然科学基金等6项省部级以上课题资助，申请专利10余项，研究成果获得广东省科技进步一等奖（排名第2）、教育部高等学校科技进步二等奖（排名第2）及中国专利优秀奖（排名第3），在Nat Commun、Cell Death &Diff、Signal Transduct Target Ther、 Redox Biol、Acta Pharm Sin B、Theranostics等期刊上发表论文60多篇。

主要研究方向：

1．药理学（免疫药理学、抗病毒药理学、中药抗感染药理学）

教育和工作经历：

 2003/09–2007/07：江西中医药大学，402永利集团官网，药学/学士

 2007/09–2010/06：永利集团，402永利集团官网，药理学/硕士

 2010/09–2013/06：永利集团，402永利集团官网，生物医药工程/博士

 2013/07–2015/09：永利集团，402永利集团官网，讲师

 2015/10–2020/09：永利集团，402永利集团官网，副教授

 2020/10–至今：永利集团，402永利集团官网，教授

主要学术奖励：

1. 广东省科技进步一等奖，2018年，排名第二

2. 教育部科学技术进步二等奖，2018年，排名第二

3. 中国专利优秀奖，2015年，排名第三

  获人才项目：

1. 国家级人才项目（2020年）：教育部重大人才项目青年学者

2. 省级人才项目（2017年）：广东省人才

3. 省级人才项目（2017年）：广东省自然科学杰出青年

4. 市级人才项目（2016年）：广州市珠江科技新星计划

近年发表的主要英文论文

1. Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS. Signal Transduct Target Ther. 2020, 5(1):202. (IF=13.493)

2. Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Cell Death Differ. 2021, 28(6):1971-1989 (IF=15.828)

3. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun. 2020 11(1):1473. (IF=14.919)

4. Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage. Redox Biol. 2018, 14:1-6. (IF=11.799)

5. Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone. Theranostics. 2020 Jul 11;10(20):9032-9049.  (IF=11.556)

6. Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy. Theranostics. 2018; 8(20):5713-5730. (IF=11.556)

7. Inhibitory effects of baicalein against herpes simplex virus type 1. Acta Pharm Sin B. 2020,Dec 10(12):2323-2338. (IF=11.413)

8. Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm Sin B. 2020 Mar 10(3):383-398. (IF=11.413)

9. Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3. Phytomedicine, 2021, 80:153398.

10. New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention. Phytomedicine. 2017, 27:52-62.

11. Fostering efficacy and toxicity evaluation of traditional Chinese medicine and natural products: Chick embryo as a high throughput model bridging in vitro and in vivo studies. Pharmacol Res.2018,133:21-34. (IF=7.658)

12. A comparative analysis of chemical compositions in Camellia sinensis var. puanensis Kurihara, a novel Chinese tea, by HPLC and UFLC-Q-TOF-MS/MS. Food Chem.2017. 216:282-8.(IF= 7.514)

13. “Shanghuo” increases disease susceptibility: Modern significance of an old TCM theory. Journal of Ethnopharmacology.2020, 250:112491.

14. Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host. INT J MOL SCI . 2018, 19: 3266-3288.

15. Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro. Front Pharmacol. 2019 Feb 7;10:78.

16. Sirt3-dependent deacetylation of COX-1 counteracts oxidative stress–induced cell apoptosis. The FEBS Journal 2019, 33(22): 14118-14128.

17. “Shanghuo” increases disease susceptibility: Modern significance of an old TCM theory. Journal of Ethnopharmacology.2020, 250: 112491.

18. Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases. Front. Pharmacol.2020, 10: 1564.

19. Immune regulation effect of lienal polypeptides extract in Lewis lung carcinoma-bearing mice treated with cyclophosphamide. Exp Biol Med.2018, 243(1):66-77.

20. Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. Metabolism.2018,85:227-39.

联系方式：

地址：广州黄埔大道西 601号 永利集团 402永利集团官网七楼  

Email：liyifang706@jnu.edu.cn