1. 个人简介：

黄维娟，博士，副研究员，硕士生导师。2008年获药学学士学位，2011年获药理学专业硕士学位，2019获中药药理学专业博士学位，2020年8月以第四层次人才绿色通道入职402永利集团官网。目前承担国家自然科学基金青年项目及省市校等各级科研项目5项，以第一/共一作者身份在Oncogene, Leukemia, Mol Cancer, Clinic Cancer Res, Ind Crops Prod, Int J Biol Macromol, Oncotarget, Am J Chin Med等杂志发表论文10余篇。参编专著1部，申请发明专利1项。欢迎有志于药理学研究的学生提前和我联系，报考和申请加入我的研究团队。

2. 研究方向：

（1）中药抗肿瘤药理学；

（2）肿瘤耐药分子标签；

（3）临床医学转化。

     3. 主持的科研项目：

（1）青蒿素B靶向LINC00663调控晚期非小细胞肺癌耐药的机理研究（2020M673091），中国博士后科学基金第67批面上资助，2020年6月-2022年3月，主持，在研；

（2）基于长链非编码RNA LINC00663调控miR-194-3P表达探究晚期非小细胞肺癌耐药的分子机制及青蒿素B的干预机理（82003774），国家自然科学基金青年基金，2021年1月-2023年12月，主持，在研。

（3）环状RNA Circ-UNP155通过调控穹隆体RNA vtRNA1-3的表达影响T淋巴母细胞淋巴瘤/白血病复发耐药的机制研究，广东省自然科学基金面上项目，2023年1月-2025年12月，主持，在研。

     4. 近五年的代表性论文

（1）Huang Wei-juan^#, Wang Yan-qing^#, He Ting-sha^#, Zhu Jian-hua, Li Jian-huan, Zhang Si-rui, Zhu Yong , Xu Ya-fang, Xu Lv, Wang Hao-ran, Yu Rong-min^* and Song Li-yan^*. Arteannuin B Enhances the Effectiveness of Cisplatin in Non-Small Cell Lung Cancer by Regulating Connexin 43 and MAPK Pathway. The American Journal of Chinese Medicine. 2022; 31:1-30.

（2）Luo Yuan yuan^#, Li Chun-lei^#, He Ting-sha, Huang Wei-juan^#, Wang Yu-rong, Yu Dong-Bo, Ma Min^#, Yu Rong-min, Zhu Jian-hua^*, Song Li-yan^*. A highly branched α-d-glucan facilitates antitumor immunity by reducing cancer cell CXCL5 expression. International Journal of Biological Macromolecules, 2022; 209:166-179.

（3）WangYan-qing^#, HuangWei-juan^#, WangNan-nan, OuyangDe-fang, XiaoLi-feng, ZhangSi-rui, OuXiao-zheng, HeTing-sha, YuRong-min^*, and SongLi-yan^*. Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches. Pharmaceutics. 2021; 13(8):1236.

（4）Guo Song-bin^#, Huang Wei-juan^*, Tian Xiao-Peng^*. Brusatol modulates diverse cancer hallmarks and signaling pathways as a potential cancer therapeutic. Acta Medica Mediterranea.2022; doi.org/ 10.15212/AMM-2022-0014.

（5）HuangWei-Juan^#,Tian Xiao-Peng^#,Bi Si-Xue^#,Zhang Si-Rui^#, HeTing-Sha, Song Li-Yan, Yun Jing-Ping, Zhou Zhong-Guo, Yu Rong-Min*,LiMei*. Theβ-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis. Oncogene, 2020 Jun;39(23):4538-4550.

（6）Tian Xiao-Peng^#; Huang Wei-Juan^#; Huang Hui-Qiang^#; Liu Yan-Hui; Wang Liang; Zhang Xi; Lin Tong-Yu; Rao Hui-Lan; Li Mei; Liu Fang; Zhang Fen; Zhong Li-Ye; Liang Li; Lan Xiao-Liang; Li Juan; Liao Bing; Li Zhi-Hua; Tang Qiong-Lan; Liang Qiong; Shao Chun-Kui; Zhai Qiong-Li; Cheng Run-Fen; Sun Qi; Ru Kun; Gu Xia; Lin Xi-Na; Yi Kun; Shuang Yue-Rong; Chen Xiao-Dong; Dong Wei; Sang Wei; Sun Cai; Li Hui; Zhu Zhi-Gang; Rao Jun; Guo Qiao-Nan; Zhou Ying; Meng Xiang-Ling; Zhu Yong; Hu Chang-Lu; Jiang Yi-Rong; Zhang Ying; Gao Hong-Yi; He Wen-Jun; Xia Zhong-Jun; Wu Cheng-Lei; Zhang Mei-Yin; Wang Hui-Yun; Xie Dan* ; Cai Qing-Qing*; Prognosti c and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma.Leukemia, 2019, 33(10): 2454-2465.

（7）Tian Xiao-Peng^#; Xie Dan^#; Huang Wei-Juan^#; Ma Shu-Yun^#; Wang Liang; Liu Yan-Hui; Zhang Xi; Huang Hui-Qiang; Lin Tong-Yu; Rao Hui-Lan; Li Mei, Liu Fang; Zhang Fen; Zhong Li-Ye; Liang Li; Lan Xiao-Liang; Li Juan; Liao Bing; Li Zhi-Hua; Tang Qiong-Lan; Liang Qiong ; Shao Chun-Kui; Zhai Qiong-Li; Cheng Run-Fen; Sun Qi; Ru Kun; Gu Xia; Lin Xi-Na; Yi Kun; Shuang Yue-Rong; Chen Xiao-Dong;  Dong Wei; Sang Wei; Sun Cai; Liu Hui; Zhu Zhi-Gang; Rao Jun; Guo Qiao-Nan; Zhou Ying; Meng Xiang-Ling; Zhu Yong; Hu Chang-Lu;  Jiang Yi-Rong; Zhang Ying; Gao Hong-Yi; He Wen-Jun; Xia Zhong-Jun;  Pan Xue-Yi; Lan Hai; Li Guo-Wei; Liu Lu; Bao Hui-Zheng; Song Li-Yan ; Kang Tie-Bang; Cai Qing-Qing*. A gene-expression-based signature predicts survival in adults with T-cell lymphoblastic lymphoma: a multicenter study. Leukemia, 2020. 34(9): 2392-2404.

（8）Peng Bao^#; Yang Jia-ning^#; Huang Wei-juan^#; Peng Dan; Bi Si-xue; Song Li-yan*; Wen Yao; Zhu Jian-hua*; Chen Yi-yu; Yu Rong-min*. Structural characterization and immunoregulatory activity of a novel heteropolysaccharide from bergamot (Citrus medica L. var. sarcodactylis) by alkali extraction. Industrial Crops and Products, 2019, 140: 0-UNSP 111617. 

（9）Tian Xiao-Peng^#; Jin Xiao-Han^#; Li Mei^#; Huang Wei-Juan^#; Xie Dan; Zhang Jia-Xing*; The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway. Molecular Cancer, 2017, 16(1): 0-74. 

（10）Tian Xiao-Peng^#, Su Ning^#, Wang Liang^#, Huang Wei-Juan^#, Liu Yan-Hui, Zhang Xi, Huang Hui-Qiang, Lin Tong-Yu, Ma Shu-Yun, Rao Hui-Lan, Li Mei, Liu Fang, Zhang Fen, Zhong Li-Ye, Liang Li, Lan Xiao-Liang, Li Juan, Liao Bing, Li Zhi-Hua, Tang Qiong-Lan, Liang Qiong, Shao Chun-Kui, Zhai Qiong-Li, Cheng Run-Fen, Sun Qi, Ru Kun, Gu Xia, Lin Xi-Na, Yi Kun, Shuang Yue-Rong, Chen Xiao-Dong, Dong Wei, Sang Wei,  Sun Cai, Liu Hui, Zhu Zhi-Gang, Rao Jun, Guo Qiao-Nan, Zhou Ying,  Meng Xiang-Ling, Zhu Yong, Hu Chang-Lu, Jiang Yi-Rong, Zhang Ying,  Gao Hong-Yi, He Wen-Jun, Xia Zhong-Jun, Pan Xue-Yi, Hai Lan, Li Guo-Wei, Song Li-Yan, Kang Tie-Bang, Xie Dan^*, Cai Qing-Qing^*. Predictive Value of a CpG Methylation Classifier for Relapse in Adults with T-cell Lymphoblastic Lymphoma: a multicentre study. Clinic Cancer Research, 2020, 26(14): 3760-3770.

（11）Huang Wei-Juan^#; Li Mei^#; Jin Xiao-Han^#; Huang Xiao-Jia; Zhao Wei; Tian Xiao-Peng*. Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas. Oncotarget, 2017, 8(40): 67241-67253.

（12）Bi Si-xue^#; Huang Wei-juan^#; Chen Shan; Huang Chun-hua; Li Chun-lei; Guo Zhong-yi; Yang Jia-ning; Zhu Jian-hua*; Song Li-yan*;  Yu Rong-min**. Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes. International Journal of Biological Macromolecules, 2020, 150: 261-280.

     5. 联系方式