何亮亮副教授简介

1. 个人简介：

何亮亮，博士，副教授，主要研究方向为中药（复方）药效物质基础及质量控制方法研究；研究兴趣围绕基于LC-MS技术的中药（复方）复杂化学体系表征和体内代谢特征研究，及在此基础上的质量标志物的发现和质量控制方法体系的构建和应用。近年来，作为项目负责人，主持国自然青年基金、省自然面上基金、省青年基金等各类项目6项，作为骨干参加了国家重点研发计划、国自然重点项目，以第一或通讯作者在 Phytomedicine、Food Chem、J Chromatogr A等国际学术期刊上发表 SCI 论文18篇，其中一区或TOP期刊论文12篇。

2. 讲授课程：

（1）本科生课程：《药物分析》、《现代分析技术》

（3）研究生课程：《中药质量控制》

3. 研究方向：

（1）中药药物代谢动力学：基于高分辨质谱技术的中药及复方多成分复杂体系

体内代谢处置特征及作用机制研究；

（2）中药质量控制研究：基于色谱及联用技术的中药及复方整体质量控制方法研究；

4. 主要学术兼职：

(1) 广东省生物医药健康促进会委员

5. 代表性科研项目：

（1）国家自然科学基金—青年基金项目，24万元，主持；

（2）广东省自然科学基金—面上项目，15.0万，主持；

（3）广东省基础与应用基础研究基金—青年基金项目，10万元，主持。

（4）国家药品监督管理局中药质量研究与评价重点实验室—开放课题，9.0万，主持；

（5）广州市基础与应用基础研究专题—青年博士“启航”项目，5.0万元，主持；

（6）永利集团中央高校基本科研项目—专用项目，8.0万，主持；

6.研究论文：

[1] A multi-module structure labelled molecular network orients the chemical profiles of traditional Chinese medicine prescriptions: Xiaoyao San, as an example[J]. Journal of Chromatography A, 2024, 1715: 464613.（TOP期刊，共一）

[2] The role of BDNF transcription in the antidepressant-like effects of 18β-glycyrrhetinic acid in a chronic social defeat stress model[J]. Phytomedicine, 2023: 155332.（1区、TOP期刊，共一）

[3] Activity labelled molecular networking fuels the antioxidation active molecules profile of Ginger[J]. Food Chemistry, 2023, 424: 136343.（1区、TOP期刊，通讯）

[4] An efficient strategy for large‐scale preparation of low polarity gingerols directly from ginger crude extract by high‐speed countercurrent chromatography with different rotation mode[J]. Journal of Separation Science, 2023, 46(19): 2300320.（通讯）

[5] A compounds annotation strategy using targeted molecular networking for offline two-dimensional liquid chromatography-mass spectrometry analysis: Yupingfeng as a case study[J]. Journal of Chromatography A, 2023, 1702: 464045. （TOP期刊，共一）

[6] Regulation of phospholipid peroxidation signaling by a traditional Chinese medicine formula for coronary heart disease[J]. Phytomedicine, 2023, 114: 154749.（1区、TOP期刊，通讯）

[7] Quality assessment of commercial dried ginger (Zingiber officinale Roscoe) based on targeted and non-targeted chemical profiles and anti-inflammatory activity[J]. Food Research International, 2023, 166: 112589. （1区、TOP期刊，共一）

[8] Development of a three-step-based novel strategy integrating DMPK with network pharmacology and bioactivity evaluation for the discovery of Q-markers of traditional Chinese medicine prescriptions: Danlou tablet as an example[J]. Phytomedicine, 2023, 108: 154511. （1区、TOP期刊，通讯）

[9] Cytochrome P450 metabolism studies of [6]-gingerol,[8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes[J]. RSC advances, 2023, 13(9): 5804-5812.（通讯）

[10] Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule[J]. The Journal of Steroid Biochemistry and Molecular Biology, 2023, 225: 106182.（共一）

[11] Ab initio calculation based solvent system selection in silico for counter-current chromatography: Separation of resibufogenin glycosylation products[J]. Journal of Chromatography A, 2022, 1686: 463649. （TOP期刊，通讯）

[12] Bufadienolides originated from toad source and their anti-inflammatory activity[J]. Frontiers in Pharmacology, 2022, 13: 1044027. （TOP期刊，通讯）

[13] Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens[J]. Frontiers in Pharmacology, 2022, 13: 935685.（TOP期刊，共一）

[14] Chemical profile and potential mechanisms of Huo-Tan-Chu-Shi decoction in the treatment of coronary heart disease by UHPLC-Q/TOF-MS in combination with network pharmacology analysis and experimental verification[J]. Journal of Chromatography B, 2021, 1175: 122729. （共一）

[15] The discovery of Q-markers of Qiliqiangxin Capsule, a traditional Chinese medicine prescription in the treatment of chronic heart failure, based on a novel strategy of multi-dimensional “radar chart” mode evaluation[J]. Phytomedicine, 2021, 82: 153443. （1区、TOP期刊，共一）

[16] An efficient strategy based on liquid‐liquid extraction and pH‐zone‐refining counter‐current chromatography for selective enrichment, separation, and purification of alkaloids and organic Acids from natural products[J]. Journal of Separation Science, 2020, 43(18): 3607-3614.（通讯）

[17] Metabolic profiles of ginger, a functional food, and its representative pungent compounds in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry[J]. Journal of agricultural and food chemistry, 2018, 66(34): 9010-9033. （1区、TOP期刊，共一）

[18] Glucuronidation of [6]-shogaol,[8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor[J]. RSC advances, 2018, 8(72): 41368-41375.（共一）

7. 授权专利：

[1] 一种基于UPLC-TQ-MS/MS的干姜质量评价方法.专利号：ZL 2021 1 1521541.5

[2] 一种逍遥丸UPLC指纹图谱的构建方法及其应用.专利号：ZL 2021 1 1522796.3

[3] 芒柄花黄素在制备治疗或/和预防抑郁症药物中的应用.专利号：ZL 2021 1 0745850.4